Epidemiological and Molecular Analysis of an Outbreak of Highly Pathogenic Avian Influenza H5N8 clade 2.3.4.4 in a German Zoo: Effective Disease Control with Minimal Culling.
Identifieur interne : 000061 ( Main/Exploration ); précédent : 000060; suivant : 000062Epidemiological and Molecular Analysis of an Outbreak of Highly Pathogenic Avian Influenza H5N8 clade 2.3.4.4 in a German Zoo: Effective Disease Control with Minimal Culling.
Auteurs : A. Globig [Allemagne] ; E. Starick [Allemagne] ; T. Homeier [Allemagne] ; A. Pohlmann [Allemagne] ; C. Grund [Allemagne] ; P. Wolf [Allemagne] ; A. Zimmermann [Allemagne] ; C. Wolf [Allemagne] ; D. Heim [Allemagne] ; H. Schlö Er [Allemagne] ; S. Zander [Allemagne] ; M. Beer [Allemagne] ; F J Conraths [Allemagne] ; T C Harder [Allemagne]Source :
- Transboundary and emerging diseases [ 1865-1682 ] ; 2017.
Descripteurs français
- KwdFr :
- Allemagne (épidémiologie), Analyse de séquence d'ADN (médecine vétérinaire), Animaux, Animaux de zoo, Flambées de maladies (médecine vétérinaire), Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (virologie), Grippe chez les oiseaux (épidémiologie), Oiseaux, Phylogénie, Sous-type H5N8 du virus de la grippe A (génétique), Sous-type H5N8 du virus de la grippe A (immunologie), Sous-type H5N8 du virus de la grippe A (isolement et purification), Sous-type H5N8 du virus de la grippe A (pathogénicité), Séquençage nucléotidique à haut débit (médecine vétérinaire), Élimination des animaux.
- MESH :
- anatomopathologie : Grippe chez les oiseaux.
- génétique : Sous-type H5N8 du virus de la grippe A.
- immunologie : Sous-type H5N8 du virus de la grippe A.
- isolement et purification : Sous-type H5N8 du virus de la grippe A.
- médecine vétérinaire : Analyse de séquence d'ADN, Flambées de maladies, Séquençage nucléotidique à haut débit.
- pathogénicité : Sous-type H5N8 du virus de la grippe A.
- virologie : Grippe chez les oiseaux.
- épidémiologie : Allemagne, Grippe chez les oiseaux.
- Animaux, Animaux de zoo, Oiseaux, Phylogénie, Élimination des animaux.
English descriptors
- KwdEn :
- Animal Culling, Animals, Animals, Zoo, Birds, Disease Outbreaks (veterinary), Germany (epidemiology), High-Throughput Nucleotide Sequencing (veterinary), Influenza A Virus, H5N8 Subtype (genetics), Influenza A Virus, H5N8 Subtype (immunology), Influenza A Virus, H5N8 Subtype (isolation & purification), Influenza A Virus, H5N8 Subtype (pathogenicity), Influenza in Birds (epidemiology), Influenza in Birds (pathology), Influenza in Birds (virology), Phylogeny, Sequence Analysis, DNA (veterinary).
- MESH :
- epidemiology : Germany, Influenza in Birds.
- genetics : Influenza A Virus, H5N8 Subtype.
- immunology : Influenza A Virus, H5N8 Subtype.
- isolation & purification : Influenza A Virus, H5N8 Subtype.
- pathogenicity : Influenza A Virus, H5N8 Subtype.
- pathology : Influenza in Birds.
- veterinary : Disease Outbreaks, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA.
- virology : Influenza in Birds.
- Animal Culling, Animals, Animals, Zoo, Birds, Phylogeny.
Abstract
Outbreaks of highly pathogenic avian influenza A virus (HPAIV) subtype H5N8, clade 2.3.4.4, were first reported in January 2014 from South Korea. These viruses spread rapidly to Europe and the North American continent during autumn 2014 and caused, in Germany, five outbreaks in poultry holdings until February 2015. In addition, birds kept in a zoo in north-eastern Germany were affected. Only a few individual white storks (Ciconia ciconia) showed clinical symptoms and eventually died in the course of the infection, although subsequent in-depth diagnostic investigations showed that other birds kept in the same compound of the white storks were acutely positive for or had undergone asymptomatic infection with HPAIV H5N8. An exception from culling all of the 500 remaining zoo birds was granted by the competent authority. Restriction measures included grouping the zoo birds into eight epidemiological units in which 60 birds of each unit tested repeatedly negative for H5N8. Epidemiological and phylogenetical investigations revealed that the most likely source of introduction was direct or indirect contact with infected wild birds as the white storks had access to a small pond frequented by wild mallards and other aquatic wild birds during a period of 10 days in December 2014. Median network analysis showed that the zoo bird viruses segregated into a distinct cluster of clade 2.3.4.4 with closest ties to H5N8 isolates obtained from mute swans (Cygnus olor) in Sweden in April 2015. This case demonstrates that alternatives to culling exist to rescue valuable avifaunistic collections after incursions of HPAIV.
DOI: 10.1111/tbed.12570
PubMed: 27860371
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Heim</name><affiliation wicri:level="1"><nlm:affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Schlo Er, H" sort="Schlo Er, H" uniqKey="Schlo Er H" first="H" last="Schlö Er">H. Schlö Er</name><affiliation wicri:level="1"><nlm:affiliation>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Zander, S" sort="Zander, S" uniqKey="Zander S" first="S" last="Zander">S. Zander</name><affiliation wicri:level="1"><nlm:affiliation>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Beer, M" sort="Beer, M" uniqKey="Beer M" first="M" last="Beer">M. Beer</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Conraths, F J" sort="Conraths, F J" uniqKey="Conraths F" first="F J" last="Conraths">F J Conraths</name><affiliation wicri:level="1"><nlm:affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Harder, T C" sort="Harder, T C" uniqKey="Harder T" first="T C" last="Harder">T C Harder</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27860371</idno><idno type="pmid">27860371</idno><idno type="doi">10.1111/tbed.12570</idno><idno type="wicri:Area/Main/Corpus">000067</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000067</idno><idno type="wicri:Area/Main/Curation">000067</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000067</idno><idno type="wicri:Area/Main/Exploration">000067</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Epidemiological and Molecular Analysis of an Outbreak of Highly Pathogenic Avian Influenza H5N8 clade 2.3.4.4 in a German Zoo: Effective Disease Control with Minimal Culling.</title><author><name sortKey="Globig, A" sort="Globig, A" uniqKey="Globig A" first="A" last="Globig">A. Globig</name><affiliation wicri:level="1"><nlm:affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Starick, E" sort="Starick, E" uniqKey="Starick E" first="E" last="Starick">E. Starick</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Homeier, T" sort="Homeier, T" uniqKey="Homeier T" first="T" last="Homeier">T. Homeier</name><affiliation wicri:level="1"><nlm:affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Pohlmann, A" sort="Pohlmann, A" uniqKey="Pohlmann A" first="A" last="Pohlmann">A. Pohlmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Grund, C" sort="Grund, C" uniqKey="Grund C" first="C" last="Grund">C. Grund</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, P" sort="Wolf, P" uniqKey="Wolf P" first="P" last="Wolf">P. Wolf</name><affiliation wicri:level="1"><nlm:affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Zimmermann, A" sort="Zimmermann, A" uniqKey="Zimmermann A" first="A" last="Zimmermann">A. Zimmermann</name><affiliation wicri:level="1"><nlm:affiliation>Zoo Rostock GmbH, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zoo Rostock GmbH, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, C" sort="Wolf, C" uniqKey="Wolf C" first="C" last="Wolf">C. Wolf</name><affiliation wicri:level="1"><nlm:affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Heim, D" sort="Heim, D" uniqKey="Heim D" first="D" last="Heim">D. Heim</name><affiliation wicri:level="1"><nlm:affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Schlo Er, H" sort="Schlo Er, H" uniqKey="Schlo Er H" first="H" last="Schlö Er">H. Schlö Er</name><affiliation wicri:level="1"><nlm:affiliation>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Zander, S" sort="Zander, S" uniqKey="Zander S" first="S" last="Zander">S. Zander</name><affiliation wicri:level="1"><nlm:affiliation>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Beer, M" sort="Beer, M" uniqKey="Beer M" first="M" last="Beer">M. Beer</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Conraths, F J" sort="Conraths, F J" uniqKey="Conraths F" first="F J" last="Conraths">F J Conraths</name><affiliation wicri:level="1"><nlm:affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Harder, T C" sort="Harder, T C" uniqKey="Harder T" first="T C" last="Harder">T C Harder</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>Greifswald-Insel Riems</wicri:noRegion></affiliation></author></analytic><series><title level="j">Transboundary and emerging diseases</title><idno type="eISSN">1865-1682</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal Culling</term><term>Animals</term><term>Animals, Zoo</term><term>Birds</term><term>Disease Outbreaks (veterinary)</term><term>Germany (epidemiology)</term><term>High-Throughput Nucleotide Sequencing (veterinary)</term><term>Influenza A Virus, H5N8 Subtype (genetics)</term><term>Influenza A Virus, H5N8 Subtype (immunology)</term><term>Influenza A Virus, H5N8 Subtype (isolation & purification)</term><term>Influenza A Virus, H5N8 Subtype (pathogenicity)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (pathology)</term><term>Influenza in Birds (virology)</term><term>Phylogeny</term><term>Sequence Analysis, DNA (veterinary)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term><term>Analyse de séquence d'ADN (médecine vétérinaire)</term><term>Animaux</term><term>Animaux de zoo</term><term>Flambées de maladies (médecine vétérinaire)</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Oiseaux</term><term>Phylogénie</term><term>Sous-type H5N8 du virus de la grippe A (génétique)</term><term>Sous-type H5N8 du virus de la grippe A (immunologie)</term><term>Sous-type H5N8 du virus de la grippe A (isolement et purification)</term><term>Sous-type H5N8 du virus de la grippe A (pathogénicité)</term><term>Séquençage nucléotidique à haut débit (médecine vétérinaire)</term><term>Élimination des animaux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Germany</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Analyse de séquence d'ADN</term><term>Flambées de maladies</term><term>Séquençage nucléotidique à haut débit</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Outbreaks</term><term>High-Throughput Nucleotide Sequencing</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animal Culling</term><term>Animals</term><term>Animals, Zoo</term><term>Birds</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux de zoo</term><term>Oiseaux</term><term>Phylogénie</term><term>Élimination des animaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Outbreaks of highly pathogenic avian influenza A virus (HPAIV) subtype H5N8, clade 2.3.4.4, were first reported in January 2014 from South Korea. These viruses spread rapidly to Europe and the North American continent during autumn 2014 and caused, in Germany, five outbreaks in poultry holdings until February 2015. In addition, birds kept in a zoo in north-eastern Germany were affected. Only a few individual white storks (Ciconia ciconia) showed clinical symptoms and eventually died in the course of the infection, although subsequent in-depth diagnostic investigations showed that other birds kept in the same compound of the white storks were acutely positive for or had undergone asymptomatic infection with HPAIV H5N8. An exception from culling all of the 500 remaining zoo birds was granted by the competent authority. Restriction measures included grouping the zoo birds into eight epidemiological units in which 60 birds of each unit tested repeatedly negative for H5N8. Epidemiological and phylogenetical investigations revealed that the most likely source of introduction was direct or indirect contact with infected wild birds as the white storks had access to a small pond frequented by wild mallards and other aquatic wild birds during a period of 10 days in December 2014. Median network analysis showed that the zoo bird viruses segregated into a distinct cluster of clade 2.3.4.4 with closest ties to H5N8 isolates obtained from mute swans (Cygnus olor) in Sweden in April 2015. This case demonstrates that alternatives to culling exist to rescue valuable avifaunistic collections after incursions of HPAIV.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">27860371</PMID><DateCompleted><Year>2018</Year><Month>05</Month><Day>04</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1865-1682</ISSN><JournalIssue CitedMedium="Internet"><Volume>64</Volume><Issue>6</Issue><PubDate><Year>2017</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Transboundary and emerging diseases</Title><ISOAbbreviation>Transbound Emerg Dis</ISOAbbreviation></Journal><ArticleTitle>Epidemiological and Molecular Analysis of an Outbreak of Highly Pathogenic Avian Influenza H5N8 clade 2.3.4.4 in a German Zoo: Effective Disease Control with Minimal Culling.</ArticleTitle><Pagination><MedlinePgn>1813-1824</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/tbed.12570</ELocationID><Abstract><AbstractText>Outbreaks of highly pathogenic avian influenza A virus (HPAIV) subtype H5N8, clade 2.3.4.4, were first reported in January 2014 from South Korea. These viruses spread rapidly to Europe and the North American continent during autumn 2014 and caused, in Germany, five outbreaks in poultry holdings until February 2015. In addition, birds kept in a zoo in north-eastern Germany were affected. Only a few individual white storks (Ciconia ciconia) showed clinical symptoms and eventually died in the course of the infection, although subsequent in-depth diagnostic investigations showed that other birds kept in the same compound of the white storks were acutely positive for or had undergone asymptomatic infection with HPAIV H5N8. An exception from culling all of the 500 remaining zoo birds was granted by the competent authority. Restriction measures included grouping the zoo birds into eight epidemiological units in which 60 birds of each unit tested repeatedly negative for H5N8. Epidemiological and phylogenetical investigations revealed that the most likely source of introduction was direct or indirect contact with infected wild birds as the white storks had access to a small pond frequented by wild mallards and other aquatic wild birds during a period of 10 days in December 2014. Median network analysis showed that the zoo bird viruses segregated into a distinct cluster of clade 2.3.4.4 with closest ties to H5N8 isolates obtained from mute swans (Cygnus olor) in Sweden in April 2015. This case demonstrates that alternatives to culling exist to rescue valuable avifaunistic collections after incursions of HPAIV.</AbstractText><CopyrightInformation>© 2016 Blackwell Verlag GmbH.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Globig</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starick</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Homeier</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pohlmann</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grund</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zimmermann</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Zoo Rostock GmbH, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heim</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>State Laboratory of Mecklenburg-Western Pomerania for Animal Health and Food Safety, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schlößer</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zander</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hansestadt Rostock, Veterinary and Food Safety Office, Rostock, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beer</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conraths</LastName><ForeName>F J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Insitute of Epidemiology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harder</LastName><ForeName>T C</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Transbound Emerg Dis</MedlineTA><NlmUniqueID>101319538</NlmUniqueID><ISSNLinking>1865-1674</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D065136" MajorTopicYN="N">Animal Culling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000836" MajorTopicYN="N">Animals, Zoo</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001717" MajorTopicYN="N">Birds</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059014" MajorTopicYN="N">High-Throughput Nucleotide Sequencing</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071225" MajorTopicYN="N">Influenza A Virus, H5N8 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">HPAI H5N8 clade 2.3.4.4</Keyword><Keyword MajorTopicYN="N">HPAI in zoo birds</Keyword><Keyword MajorTopicYN="N">exception from culling</Keyword><Keyword MajorTopicYN="N">molecular epidemiology</Keyword><Keyword MajorTopicYN="N">white stork</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>06</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>5</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27860371</ArticleId><ArticleId IdType="doi">10.1111/tbed.12570</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Globig, A" sort="Globig, A" uniqKey="Globig A" first="A" last="Globig">A. Globig</name></noRegion><name sortKey="Beer, M" sort="Beer, M" uniqKey="Beer M" first="M" last="Beer">M. Beer</name><name sortKey="Conraths, F J" sort="Conraths, F J" uniqKey="Conraths F" first="F J" last="Conraths">F J Conraths</name><name sortKey="Grund, C" sort="Grund, C" uniqKey="Grund C" first="C" last="Grund">C. Grund</name><name sortKey="Harder, T C" sort="Harder, T C" uniqKey="Harder T" first="T C" last="Harder">T C Harder</name><name sortKey="Heim, D" sort="Heim, D" uniqKey="Heim D" first="D" last="Heim">D. Heim</name><name sortKey="Homeier, T" sort="Homeier, T" uniqKey="Homeier T" first="T" last="Homeier">T. Homeier</name><name sortKey="Pohlmann, A" sort="Pohlmann, A" uniqKey="Pohlmann A" first="A" last="Pohlmann">A. Pohlmann</name><name sortKey="Schlo Er, H" sort="Schlo Er, H" uniqKey="Schlo Er H" first="H" last="Schlö Er">H. Schlö Er</name><name sortKey="Starick, E" sort="Starick, E" uniqKey="Starick E" first="E" last="Starick">E. Starick</name><name sortKey="Wolf, C" sort="Wolf, C" uniqKey="Wolf C" first="C" last="Wolf">C. Wolf</name><name sortKey="Wolf, P" sort="Wolf, P" uniqKey="Wolf P" first="P" last="Wolf">P. Wolf</name><name sortKey="Zander, S" sort="Zander, S" uniqKey="Zander S" first="S" last="Zander">S. Zander</name><name sortKey="Zimmermann, A" sort="Zimmermann, A" uniqKey="Zimmermann A" first="A" last="Zimmermann">A. Zimmermann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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